Cardioprotective Effect of SEA0400, a Selective Inhibitor of the Na+/Ca2+ Exchanger, on Myocardial Ischemia-Reperfusion Injury in Rats

• Main Authors: Minoru Yoshiyama (Author), Yasuhiro Nakamura (Author), Takashi Omura (Author), Tetsuya Hayashi (Author), Yasuhiro Takagi (Author), Takao Hasegawa (Author), Hiroki Nishioka (Author), Kazuhide Takeuchi (Author), Hiroshi Iwao (Author), Junichi Yoshikawa (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we investigated whether the Na+/Ca2+ exchanger (NCX) inhibitor SEA0400 (2-[4-[(2,5-difluorophenyl)methoxy]phenoxy-5-ethoxyaniline) might have a protective effect against myocardial ischemia-reperfusion injury in rats. In particular, we focused on cardiac function using Doppler echocar...