Dehydration affects drug transport over nasal mucosa

• Main Authors: Abdullah Ali (Author), Marie Wahlgren (Author), Birgitta Rembratt-Svensson (Author), Ameena Daftani (Author), Peter Falkman (Author), Per Wollmer (Author), Johan Engblom (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Formulations for nasal drug delivery often rely on water sorption to adhere to the mucosa, which also causes a higher water gradient over the tissue and subsequent dehydration. The primary aim of this study was therefore to evaluate mucosal response to dehydration and resolve the hypothesis that muc...