TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity

• Main Authors: Harshad S. Ugamraj (Author), Kevin Dang (Author), Laure-Hélène Ouisse (Author), Benjamin Buelow (Author), Eduardo N. Chini (Author), Giulia Castello (Author), James Allison (Author), Starlynn C Clarke (Author), Laura M. Davison (Author), Roland Buelow (Author), Rong Deng (Author), Suhasini Iyer (Author), Ute Schellenberger (Author), Sankar N. Manika (Author), Shipra Bijpuria (Author), Astrid Musnier (Author), Anne Poupon (Author), Maria Cristina Cuturi (Author), Wim van Schooten (Author), Pranjali Dalvi (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cluster of differentiation 38 (CD38) is an ecto-enzyme expressed primarily on immune cells that metabolizes nicotinamide adenine dinucleotide (NAD+) to adenosine diphosphate ribose or cyclic ADP-ribose and nicotinamide. Other substrates of CD38 include nicotinamide adenine dinucleotide phosphate and...