Physicochemical and dissolution profile characterization of pellets containing different binders obtained by the extrusion-spheronization process

• Main Authors: Michele Georges Issa (Author), Letícia Pessole (Author), Andrea Ikeda Takahashi (Author), Newton Andréo Filho (Author), Humberto Gomes Ferraz (Author)
• Format: Book
• Published: Universidade de São Paulo, 2012-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

With the purpose of evaluating the behavior of different polymers employed as binders in small-diameter pellets for oral administration, we prepared formulations containing paracetamol and one of the following polymers: PVP, PEG 1500, hydroxypropylmethylcellulose and methylcellulose, and we evaluate...