SOD1 Is an Integral Yet Insufficient Oxidizer of Hydrogen Sulfide in Trisomy 21 B Lymphocytes and Can Be Augmented by a Pleiotropic Carbon Nanozyme

SOD1 Is an Integral Yet Insufficient Oxidizer of Hydrogen Sulfide in Trisomy 21 B Lymphocytes and Can Be Augmented by a Pleiotropic Carbon Nanozyme

Down syndrome (DS) is a multisystemic disorder that includes accelerated aging caused by trisomy 21. In particular, overexpression of cystathionine-β-synthase (CBS) is linked to excess intracellular hydrogen sulfide (H<sub>2</sub>S), a mitochondrial toxin at higher concentrations, which...

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Main Authors: Karthik Mouli (Author), Anton V. Liopo (Author), Larry J. Suva (Author), Kenneth R. Olson (Author), Emily A. McHugh (Author), James M. Tour (Author), Paul J. Derry (Author), Thomas A. Kent (Author)
Format: Book
Published: MDPI AG, 2024-11-01T00:00:00Z.
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3rd Floor Main Library

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