A Novel PD-L1-targeting Antagonistic DNA Aptamer With Antitumor Effects

• Ngā kaituhi matua: Wei-Yun Lai (Author), Bo-Tsang Huang (Author), Jen-Wei Wang (Author), Pei-Ying Lin (Author), Pan-Chyr Yang (Author)
• Hōputu: Pukapuka
• I whakaputaina: Elsevier, 2016-01-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

The PD-1/PD-L1 axis is a major pathway involved in tumor immune evasion. Here, we report the novel PD-L1 antagonizing DNA aptamer (aptPD-L1) and demonstrate an integrated pipeline that expedites therapeutic aptamer development. Aptamer can exert antibody-mimic functions and is advantageous over anti...