Development of Potential Multi-Target Inhibitors for Human Cholinesterases and Beta-Secretase 1: A Computational Approach

• Asıl Yazarlar: Deyse B. Barbosa (Yazar), Mayra R. do Bomfim (Yazar), Tiago A. de Oliveira (Yazar), Alisson M. da Silva (Yazar), Alex G. Taranto (Yazar), Jorddy N. Cruz (Yazar), Paulo B. de Carvalho (Yazar), Joaquín M. Campos (Yazar), Cleydson B. R. Santos (Yazar), Franco H. A. Leite (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2023-11-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Alzheimer's disease causes chronic neurodegeneration and is the leading cause of dementia in the world. The causes of this disease are not fully understood but seem to involve two essential cerebral pathways: cholinergic and amyloid. The simultaneous inhibition of AChE, BuChE, and BACE-1, essen...