Dynamic MAPK signaling activity underlies a transition from growth arrest to proliferation in Drosophila scribble mutant tumors

• Автори: Tiantian Ji (Автор), Lina Zhang (Автор), Mingxi Deng (Автор), Shengshuo Huang (Автор), Ying Wang (Автор), Tri Thanh Pham (Автор), Andrew Alan Smith (Автор), Varun Sridhar (Автор), Clemens Cabernard (Автор), Jiguang Wang (Автор), Yan Yan (Автор)
• Формат: Книга
• Опубліковано: The Company of Biologists, 2019-08-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Human tumors exhibit plasticity and evolving capacity over time. It is difficult to study the mechanisms of how tumors change over time in human patients, in particular during the early stages when a few oncogenic cells are barely detectable. Here, we used a Drosophila tumor model caused by loss of...