Dynamic MAPK signaling activity underlies a transition from growth arrest to proliferation in Drosophila scribble mutant tumors

• Main Authors: Tiantian Ji (Author), Lina Zhang (Author), Mingxi Deng (Author), Shengshuo Huang (Author), Ying Wang (Author), Tri Thanh Pham (Author), Andrew Alan Smith (Author), Varun Sridhar (Author), Clemens Cabernard (Author), Jiguang Wang (Author), Yan Yan (Author)
• Format: Book
• Published: The Company of Biologists, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human tumors exhibit plasticity and evolving capacity over time. It is difficult to study the mechanisms of how tumors change over time in human patients, in particular during the early stages when a few oncogenic cells are barely detectable. Here, we used a Drosophila tumor model caused by loss of...