Small‐molecule‐mediated chemical knock‐down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure

• Main Authors: Volker Adams (Author), T. Scott Bowen (Author), Sarah Werner (Author), Peggy Barthel (Author), Christina Amberger (Author), Anne Konzer (Author), Johannes Graumann (Author), Peter Sehr (Author), Joe Lewis (Author), Jan Provaznik (Author), Vladimir Benes (Author), Petra Büttner (Author), Alexander Gasch (Author), Norman Mangner (Author), Christian C. Witt (Author), Dittmar Labeit (Author), Axel Linke (Author), Siegfried Labeit (Author)
• Format: Book
• Published: Wiley, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Chronic heart failure (CHF) leads to diaphragm myopathy that significantly impairs quality of life and worsens prognosis. In this study, we aimed to assess the efficacy of a recently discovered small‐molecule inhibitor of MuRF1 in treating CHF‐induced diaphragm myopathy and loss...