Astragalus polysaccharides attenuate rat aortic endothelial senescence via regulation of the SIRT-1/p53 signaling pathway

• Main Authors: Xinyu Miao (Author), Lingjun Rong (Author), Bo Fu (Author), Shaoyuan Cui (Author), Zhaoyan Gu (Author), Fan Hu (Author), Yanhui Lu (Author), Shuangtong Yan (Author), Banruo Sun (Author), Wenli Jiang (Author), Yuting Zhang (Author), Yanping Gong (Author), Chunlin Li (Author)
• Format: Book
• Published: BMC, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Astragalus polysaccharides (APS) have been verified to have antioxidative and antiaging activities in the mouse liver and brain. However, the effect of APS on aortic endothelial senescence in old rats and its underlying mechanism are currently unclear. Here, we aimed to elucidate...