A method to reduce ancestry related germline false positives in tumor only somatic variant calling

• Main Authors: Rebecca F. Halperin (Author), John D. Carpten (Author), Zarko Manojlovic (Author), Jessica Aldrich (Author), Jonathan Keats (Author), Sara Byron (Author), Winnie S. Liang (Author), Megan Russell (Author), Daniel Enriquez (Author), Ana Claasen (Author), Irene Cherni (Author), Baffour Awuah (Author), Joseph Oppong (Author), Max S. Wicha (Author), Lisa A. Newman (Author), Evelyn Jaigge (Author), Seungchan Kim (Author), David W. Craig (Author)
• Format: Book
• Published: BMC, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Significant clinical and research applications are driving large scale adoption of individualized tumor sequencing in cancer in order to identify tumors-specific mutations. When a matched germline sample is available, somatic mutations may be identified using comparative callers....