Widespread distribution of a newly found point mutation in voltage-gated sodium channel in pyrethroid-resistant Aedes aegypti populations in Vietnam.

• Main Authors: Hitoshi Kawada (Author), Yukiko Higa (Author), Osamu Komagata (Author), Shinji Kasai (Author), Takashi Tomita (Author), Nguyen Thi Yen (Author), Luu Lee Loan (Author), Rodrigo A P Sánchez (Author), Masahiro Takagi (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Resistance of Aedes aegypti to photostable pyrethroid insecticides is a major problem for disease-vector control programs. Pyrethroids target the voltage-gated sodium channel on the insects' neurons. Single amino acid substitutions in this channel associated with pyrethroid resistanc...