Genes Involved in the Transcriptional Regulation of Pluripotency Are Expressed in Malignant Tumors of the Uterine Cervix and Can Induce Tumorigenic Capacity in a Nontumorigenic Cell Line

• Main Authors: Graciela Ruiz (Author), Heriberto A. Valencia-González (Author), Delia Pérez-Montiel (Author), Felipe Muñoz (Author), Rodolfo Ocadiz-Delgado (Author), Jorge Fernández-Retana (Author), Carlos Pérez-Plasencia (Author), Osbaldo Reséndis-Antonio (Author), Patricio Gariglio (Author), Alejandro García-Carrancá (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transcription factors OCT4, SOX2, KLF4, C-MYC, and NANOG (OSKM-N) regulate pluripotency and stemness, and their ectopic expression reprograms human and murine fibroblasts that constitute the key of regenerative medicine. To determine their contribution to cell transformation, we analyzed the gene ex...