Preclinical evaluation and pilot clinical study of [18F]AlF-labeled FAPI-tracer for PET imaging of cancer associated fibroblasts

• Hauptverfasser: Kongzhen Hu (Verfasst von), Junqi Li (Verfasst von), Lijuan Wang (Verfasst von), Yong Huang (Verfasst von), Li Li (Verfasst von), Shimin Ye (Verfasst von), Yanjiang Han (Verfasst von), Shun Huang (Verfasst von), Hubing Wu (Verfasst von), Jin Su (Verfasst von), Ganghua Tang (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2022-02-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

In recent years, fibroblast activation protein (FAP) has emerged as an attractive target for the diagnosis and radiotherapy of cancers using FAP-specific radioligands. Herein, we aimed to design a novel 18F-labeled FAP tracer ([18F]AlF-P-FAPI) for FAP imaging and evaluated its potential for clinical...