Preclinical evaluation and pilot clinical study of [18F]AlF-labeled FAPI-tracer for PET imaging of cancer associated fibroblasts

• Main Authors: Kongzhen Hu (Author), Junqi Li (Author), Lijuan Wang (Author), Yong Huang (Author), Li Li (Author), Shimin Ye (Author), Yanjiang Han (Author), Shun Huang (Author), Hubing Wu (Author), Jin Su (Author), Ganghua Tang (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In recent years, fibroblast activation protein (FAP) has emerged as an attractive target for the diagnosis and radiotherapy of cancers using FAP-specific radioligands. Herein, we aimed to design a novel 18F-labeled FAP tracer ([18F]AlF-P-FAPI) for FAP imaging and evaluated its potential for clinical...