Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice

• Main Authors: Meixiang Huang (Author), Carolyn Tallon (Author), Xiaolei Zhu (Author), Kaitlyn D. J. Huizar (Author), Silvia Picciolini (Author), Ajit G. Thomas (Author), Lukas Tenora (Author), Wathsala Liyanage (Author), Francesca Rodà (Author), Alice Gualerzi (Author), Rangaramanujam M. Kannan (Author), Marzia Bedoni (Author), Rana Rais (Author), Barbara S. Slusher (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The progression of Alzheimer's disease (AD) correlates with the propagation of hyperphosphorylated tau (pTau) from the entorhinal cortex to the hippocampus and neocortex. Neutral sphingomyelinase2 (nSMase2) is critical in the biosynthesis of extracellular vesicles (EVs), which play a role in pT...