Dose Dependent Effect of Sulfamethoxazole on Inhibiting K Channel of Mouse Pancreatic β Cell

• Main Authors: Hiroshi Ogata (Author), Shigeki Kitamura (Author), Makoto Fujiwara (Author), Masaru Shimizu (Author), Chengbo Tan (Author), Songji Zhao (Author), Yuko Maejima (Author), Kenju Shimomura (Author)
• Format: Book
• Published: SAGE Publishing, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sulfamethoxazole (SMX) is widely used as an antibiotic in the clinical application with side effects of hypoglycemia. This is because SMX contains the sulfonamide structure, which closes ATP-sensitive potassium (K ATP ) channels and induces insulin secretion. However, there are no detail reports tha...