Recombinant Alpha-1 Antitrypsin as Dry Powder for Pulmonary Administration: A Formulative Proof of Concept

• Main Authors: Annalisa Bianchera (Author), Esraa'a Alomari (Author), Annalisa Michielon (Author), Gianluca Bazzoli (Author), Nicoletta Ronda (Author), Giovanni Pighini (Author), Ilaria Zanotti (Author), Carmine Giorgio (Author), Andrea Mozzarelli (Author), Ruggero Bettini (Author), Stefano Bruno (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alpha-1 antitrypsin (AAT) deficiency is a genetic disorder associated with pulmonary emphysema and bronchiectasis. Its management currently consists of weekly infusions of plasma-purified human AAT, which poses several issues regarding plasma supplies, possible pathogen transmission, purification co...