Anticipating Leucovorin Rescue Therapy in Patients with Osteosarcoma through Methotrexate Population Pharmacokinetic Model

• Main Authors: Laura Ben Olivo (Author), Pricilla de Oliveira Henz (Author), Sophia Wermann (Author), Bruna Bernar Dias (Author), Gabriel Osorio Porto (Author), Amanda Valle Pinhatti (Author), Manoela Domingues Martins (Author), Lauro José Gregianin (Author), Teresa Dalla Costa (Author), Bibiana Verlindo de Araújo (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Methotrexate (MTX), which presents high inter-individual variability, is part of the Brazilian Osteosarcoma Treatment Group (BOTG) protocol. This work aimed to develop a MTX population pharmacokinetic model (POPPK) for Brazilian children with osteosarcoma (OS) following the BOTG protocol to guide re...