Anticipating Leucovorin Rescue Therapy in Patients with Osteosarcoma through Methotrexate Population Pharmacokinetic Model

• প্রধান লেখক: Laura Ben Olivo (লেখক), Pricilla de Oliveira Henz (লেখক), Sophia Wermann (লেখক), Bruna Bernar Dias (লেখক), Gabriel Osorio Porto (লেখক), Amanda Valle Pinhatti (লেখক), Manoela Domingues Martins (লেখক), Lauro José Gregianin (লেখক), Teresa Dalla Costa (লেখক), Bibiana Verlindo de Araújo (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2024-09-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Methotrexate (MTX), which presents high inter-individual variability, is part of the Brazilian Osteosarcoma Treatment Group (BOTG) protocol. This work aimed to develop a MTX population pharmacokinetic model (POPPK) for Brazilian children with osteosarcoma (OS) following the BOTG protocol to guide re...