TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors

• Main Authors: Teagan R. Wall (Author), Brandon J. Henderson (Author), George Voren (Author), Charles R. Wageman (Author), Purnima Deshpande (Author), Bruce N. Cohen (Author), Sharon R. Grady (Author), Michael J. Marks (Author), Daniel Yohannes (Author), Paul J. Kenny (Author), Merouane Bencherif (Author), Henry A. Lester (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

(E)-5-(Pyrimidin-5-yl)-1,2,3,4,7,8-hexahydroazocine (TC299423) is a novel agonist for nicotinic acetylcholine receptors (nAChRs). We examined its efficacy, affinity, and potency for α6β2∗ (α6β2-containing), α4β2∗, and α3β4∗ nAChRs, using [125I]-epibatidine binding, whole-cell patch-clamp recordings,...