Alleviation of hippocampal necroptosis and neuroinflammation by NecroX-7 treatment after acute seizures

• Main Authors: Yihyun Roh (Author), Su Bin Lee (Author), Minseo Kim (Author), Mi-Hye Kim (Author), Hee Jung Kim (Author), Kyung-Ok Cho (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Temporal lobe epilepsy (TLE) is one of the most common neurological disorders, but still one-third of patients cannot be properly treated by current medication. Thus, we investigated the therapeutic effects of a novel small molecule, NecroX-7, in TLE using both a low [Mg2+]o-induced epileptiform act...