Evaluation of levocetirizine in beagle dog and cynomolgus monkey telemetry assays: Defining the no QTc effect profile by timepoint and concentration‐QTc analysis

• Principais autores: Michael J. Engwall (Autor), Joel Baublits (Autor), Fiona A. Chandra (Autor), Zack W. Jones (Autor), Jan Wahlstrom (Autor), Ray W. Chui (Autor), Hugo M. Vargas (Autor)
• Formato: Livro
• Publicado em: Wiley, 2023-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract In prior clinical studies, levocetirizine (LEVO) has demonstrated no effect on ventricular repolarization (QTc intervals), therefore it is a relevant negative control to assess in nonclinical assays to define low proarrhythmic risk. LEVO was tested in beagle dog and cynomolgus monkey (nonhu...