Small molecule quercetin binds MALAT1 triplex and modulates its cellular function

• Main Authors: Isha Rakheja (Author), Asgar Hussain Ansari (Author), Arjun Ray (Author), Dheeraj Chandra Joshi (Author), Souvik Maiti (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The triple-helix structure at the 3' end of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non-coding RNA, has been considered to be a target for modulating the oncogenic functions of MALAT1. This study examines the binding of quercetin-a known triplex binding molecule-...