Population Pharmacokinetics of Polymyxin B and Dosage Optimization in Renal Transplant Patients

• Main Authors: Ying Li (Author), Yang Deng (Author), Zhen-Yu Zhu (Author), Yi-Ping Liu (Author), Ping Xu (Author), Xin Li (Author), Yue-Liang Xie (Author), Heng-Chang Yao (Author), Liu Yang (Author), Bi-Kui Zhang (Author), Yan-Gang Zhou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Currently, polymyxin B has been widely used in the treatment of multidrug-resistant Gram-negative pathogen infections. Due to the limited pharmacokinetic/pharmacodynamic data, the optimal dosage regimen for the recently proposed therapeutic target of the area under the concentration-time curve over...