Old Drug, New Trick: Tilorone, a Broad-Spectrum Antiviral Drug as a Potential Anti-Fibrotic Therapeutic for the Diseased Heart

• Main Authors: Duncan Horlock (Author), David M. Kaye (Author), Catherine E. Winbanks (Author), Xiao-Ming Gao (Author), Helen Kiriazis (Author), Daniel G. Donner (Author), Paul Gregorevic (Author), Julie R. McMullen (Author), Bianca C. Bernardo (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cardiac fibrosis is associated with most forms of cardiovascular disease. No reliable therapies targeting cardiac fibrosis are available, thus identifying novel drugs that can resolve or prevent fibrosis is needed. Tilorone, an antiviral agent, can prevent fibrosis in a mouse model of lung disease....