Targeting and Efficacy of Novel mAb806-Antibody-Drug Conjugates in Malignant Mesothelioma

• Main Authors: Puey-Ling Chia (Author), Sagun Parakh (Author), Ming-Sound Tsao (Author), Nhu-An Pham (Author), Hui K. Gan (Author), Diana Cao (Author), Ingrid J. G. Burvenich (Author), Angela Rigopoulos (Author), Edward B. Reilly (Author), Thomas John (Author), Andrew M. Scott (Author)
• 格式: 图书
• 出版: MDPI AG, 2020-10-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Epidermal growth factor receptor (EGFR) is highly overexpressed in malignant mesothelioma (MM). MAb806 is a novel anti-EGFR antibody that selectively targets a tumor-selective epitope. MAb806-derived antibody drug conjugates (ADCs), ABT-414, ABBV-221 and ABBV-322, may represent a novel therapeutic s...