Effects of Isosakuranetin on Pharmacokinetic Changes of Tofacitinib in Rats with <i>N</i>-Dimethylnitrosamine-Induced Liver Cirrhosis

• Main Authors: Sung Hun Bae (Author), Hyeon Gyeom Choi (Author), So Yeon Park (Author), Sun-Young Chang (Author), Hyoungsu Kim (Author), So Hee Kim (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tofacitinib, a Janus kinase 1 and 3 inhibitor, is used to treat rheumatoid arthritis. It is mainly metabolized by the cytochromes p450 (CYP) 3A1/2 and CYP2C11 in the liver. Chronic inflammation eventually leads to cirrhosis in patients with rheumatoid arthritis. Isosakuranetin (ISN), a component of...