Poly-ε-Caprolactone Implants for Benznidazole Prolonged Release: An Alternative to Chagas Disease Oral Treatment

• Main Authors: Ana Lia Mazzeti (Author), Karolina R. Gonçalves (Author), Patrícia Ferreira Boasquívis (Author), Jamile Barbosa (Author), Bruno G. Pereira (Author), Maria de Nazaré Correia Soeiro (Author), Vanessa Carla Furtado Mosqueira (Author), Maria Terezinha Bahia (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Benznidazole (BZ) tablets are the currently prescribed treatment for Chagas disease. However, BZ presents limited efficacy and a prolonged treatment regimen with dose-dependent side effects. The design and development of new BZ subcutaneous (SC) implants based on the biodegradable poly-ɛ-caprolacton...