Dual Inhibition of Pirarubicin-Induced AKT and ERK Activations by Phenformin Sensitively Suppresses Bladder Cancer Growth

• Main Authors: Mei Peng (Author), Jun Deng (Author), Sichun Zhou (Author), Di Xiao (Author), Jiahui Long (Author), Nan Zhang (Author), Caimei He (Author), Miao Mo (Author), Xiaoping Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activations of Akt or ERK pathway induced by clinical drugs promote therapeutic failure due to decrease of drug response, and no available strategies have been developed to solve these problems. In this study, we found that pirarubicin (THP), one important chemotherapeutic drug for treating bladder...