Diverse susceptibilities and responses of human and rodent cells to orthohantavirus infection reveal different levels of cellular restriction.

• Main Authors: Giulia Gallo (Author), Petr Kotlik (Author), Philippe Roingeard (Author), Marc Monot (Author), Guillaume Chevreux (Author), Rainer G Ulrich (Author), Noël Tordo (Author), Myriam Ermonval (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Orthohantaviruses are rodent-borne emerging viruses that may cause severe diseases in humans but no apparent pathology in their small mammal reservoirs. However, the mechanisms leading to tolerance or pathogenicity in humans and persistence in rodent reservoirs are poorly understood, as is the manne...