On the Road towards Small-Molecule Programmed Cell Death 1 Ligand 1 Positron Emission Tomography Tracers: A Ligand-Based Drug Design Approach

• Main Authors: Karsten Bamminger (Author), Verena Pichler (Author), Chrysoula Vraka (Author), Tina Nehring (Author), Katharina Pallitsch (Author), Barbara Lieder (Author), Marcus Hacker (Author), Wolfgang Wadsak (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PD-1/PD-L1 immune checkpoint blockade for cancer therapy showed promising results in clinical studies. Further endeavors are required to enhance patient stratification, as, at present, only a small portion of patients with PD-L1-positive tumors (as determined by PD-L1 targeted immunohistochemistry;...