BRCA-mutated gastric adenocarcinomas are associated with chromosomal instability and responsiveness to platinum-based chemotherapy

• Main Authors: Ji Hyun Oh (Author), Chang Ohk Sung (Author), Hyung-Don Kim (Author), Sung-Min Chun (Author), Jihun Kim (Author)
• Format: Book
• Published: Korean Society of Pathologists & the Korean Society for Cytopathology, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background Homologous recombination defect is an important biomarker of chemotherapy in certain tumor types, and the presence of pathogenic or likely pathogenic mutations involving BRCA1 or BRCA2 (p-BRCA) mutations is the most well-established marker for the homologous recombination defect. Gastric...