Assessing CYP2C8-Mediated Pharmaceutical Excipient-Drug Interaction Potential: A Case Study of Tween 80 and Cremophor EL−35

• Main Authors: Chengming Wen (Author), Haoyang Hu (Author), Wenwen Zhang (Author), Xin Liu (Author), Xuehua Jiang (Author), Ling Wang (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2021-09-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Pharmaceutical excipients (PEs) are substances included in drug formulations. Recent studies have revealed that some PEs can affect the activity of metabolic enzymes and drug transporters; however, the effects of PEs on CYP2C8 and its interaction potential with drugs remain unclear. In this study, w...