Assessing CYP2C8-Mediated Pharmaceutical Excipient-Drug Interaction Potential: A Case Study of Tween 80 and Cremophor EL−35

Pharmaceutical excipients (PEs) are substances included in drug formulations. Recent studies have revealed that some PEs can affect the activity of metabolic enzymes and drug transporters; however, the effects of PEs on CYP2C8 and its interaction potential with drugs remain unclear. In this study, w...

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Main Authors: Chengming Wen (Author), Haoyang Hu (Author), Wenwen Zhang (Author), Xin Liu (Author), Xuehua Jiang (Author), Ling Wang (Author)
Format: Book
Published: MDPI AG, 2021-09-01T00:00:00Z.
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