Physiologically Based Pharmacokinetic Modelling of Cabozantinib to Simulate Enterohepatic Recirculation, Drug-Drug Interaction with Rifampin and Liver Impairment

Cabozantinib (CAB) is a receptor tyrosine kinase inhibitor approved for the treatment of several cancer types. Enterohepatic recirculation (EHC) of the substance is assumed but has not been further investigated yet. CAB is mainly metabolized via CYP3A4 and is susceptible for drug-drug interactions (...

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Hoofdauteurs: Bettina Gerner (Auteur), Oliver Scherf-Clavel (Auteur)
Formaat: Boek
Gepubliceerd in: MDPI AG, 2021-05-01T00:00:00Z.
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3rd Floor Main Library

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