Activation of the MAC1-ERK1/2-NOX2 Pathway Is Required for LPS-Induced Sustaining Reactive Microgliosis, Chronic Neuroinflammation and Neurodegeneration

• Main Authors: Shih-Heng Chen (Author), Shuangyu Han (Author), Chih-Fen Hu (Author), Ran Zhou (Author), Yun Gao (Author), Dezhen Tu (Author), Huiming Gao (Author), Jing Feng (Author), Yubao Wang (Author), Ru-Band Lu (Author), Jau-Shyong Hong (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent studies suggest that improper resolution of acute neuroinflammation may lead to long-lasting low-grade chronic neuroinflammation and drive progressive neurodegeneration. However, the molecular mechanism underlying the transition from acute to chronic neuroinflammation remains unclear. The mai...