Regulation of ROS-Dependent JNK Pathway by 2'-Hydroxycinnamaldehyde Inducing Apoptosis in Human Promyelocytic HL-60 Leukemia Cells

• मुख्य लेखकों: Kyung-Sook Chung (लेखक), Chae-Bin Yoo (लेखक), Jeong-Hun Lee (लेखक), Hwi-Ho Lee (लेखक), Sang-Eun Park (लेखक), Hee-Soo Han (लेखक), Su-Yeon Lee (लेखक), Byoung-Mok Kwon (लेखक), Jung-Hye Choi (लेखक), Kyung-Tae Lee (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The present study demonstrated that 2'-hydroxycinnamaldehyde (2'-HCA) induced apoptosis in human promyelocytic leukemia HL-60 cells through the activation of mitochondrial pathways including (1) translocation of Bim and Bax from the cytosol to mitochondria, (2) downregulation of Bcl-2 prot...