Regulation of ROS-Dependent JNK Pathway by 2'-Hydroxycinnamaldehyde Inducing Apoptosis in Human Promyelocytic HL-60 Leukemia Cells

• Main Authors: Kyung-Sook Chung (Author), Chae-Bin Yoo (Author), Jeong-Hun Lee (Author), Hwi-Ho Lee (Author), Sang-Eun Park (Author), Hee-Soo Han (Author), Su-Yeon Lee (Author), Byoung-Mok Kwon (Author), Jung-Hye Choi (Author), Kyung-Tae Lee (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study demonstrated that 2'-hydroxycinnamaldehyde (2'-HCA) induced apoptosis in human promyelocytic leukemia HL-60 cells through the activation of mitochondrial pathways including (1) translocation of Bim and Bax from the cytosol to mitochondria, (2) downregulation of Bcl-2 prot...