The Effect of Natural Health Products and Traditional Medicines on the Activity of Human Hepatic Microsomal-Mediated Metabolism of Oseltamivir

• Main Authors: Rui Liu (Author), Teresa W Tam (Author), Jingqin Mao (Author), Ammar Saleem (Author), Anthony Krantis (Author), John T Arnason (Author), Brian C Foster (Author)
• Format: Book
• Published: Frontiers Media S.A., 2010-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. Oseltamivir is a prodrug that requires metabolic activation but there is little information on whether natural health products interact to prevent the biotransformation by the carboxylesterase. Methods. HPLC-DAD-ESI-MSD and fluorometric assays were used to determine if 50-pooled mixed gende...