The Effect of Natural Health Products and Traditional Medicines on the Activity of Human Hepatic Microsomal-Mediated Metabolism of Oseltamivir

• Prif Awduron: Rui Liu (Awdur), Teresa W Tam (Awdur), Jingqin Mao (Awdur), Ammar Saleem (Awdur), Anthony Krantis (Awdur), John T Arnason (Awdur), Brian C Foster (Awdur)
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• Cyhoeddwyd: Frontiers Media S.A., 2010-02-01T00:00:00Z.
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Purpose. Oseltamivir is a prodrug that requires metabolic activation but there is little information on whether natural health products interact to prevent the biotransformation by the carboxylesterase. Methods. HPLC-DAD-ESI-MSD and fluorometric assays were used to determine if 50-pooled mixed gende...