Intra-Articular injection of acid-sensitive stearoxyl-ketal-dexamethasone microcrystals for long-acting arthritis therapy

• Main Authors: Yang Xu (Author), Ziqi Chen (Author), Zunkai Xu (Author), Yanyan Du (Author), Jianghao Han (Author), Xiaoyong Yuan (Author), Shubiao Zhang (Author), Shutao Guo (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite advances in treatment of chronic arthritis, there is still a strong need for the development of long-acting formulations that can enable local and sustained drug release at the inflamed tissues. In this work, we fabricated microcrystals of an acid-sensitive stearoxyl-ketal-dexamethasone prod...