Mechanistic Modeling of a Novel Oncolytic Virus, V937, to Describe Viral Kinetic and Dynamic Processes Following Intratumoral and Intravenous Administration

• 主要な著者: Zinnia P. Parra-Guillen (著者), Tomoko Freshwater (著者), Youfang Cao (著者), Kapil Mayawala (著者), Sara Zalba (著者), Maria J. Garrido (著者), Dinesh de Alwis (著者), Iñaki F. Troconiz (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

V937 is an investigational novel oncolytic non-genetically modified Kuykendall strain of Coxsackievirus A21 which is in clinical development for the treatment of advanced solid tumor malignancies. V937 infects and lyses tumor cells expressing the intercellular adhesion molecule I (ICAM-I) receptor....