Mapping the metabolomic and lipidomic changes in the bleomycin model of pulmonary fibrosis in young and aged mice

• Main Authors: Jelena Weckerle (Author), Sergio Picart-Armada (Author), Stephan Klee (Author), Tom Bretschneider (Author), Andreas H. Luippold (Author), Wolfgang Rist (Author), Christian Haslinger (Author), Holger Schlüter (Author), Matthew J. Thomas (Author), Bartlomiej Krawczyk (Author), Francesc Fernandez-Albert (Author), Marc Kästle (Author), Daniel Veyel (Author)
• Format: Book
• Published: The Company of Biologists, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alterations in metabolic pathways were recently recognized as potential underlying drivers of idiopathic pulmonary fibrosis (IPF), translating into novel therapeutic targets. However, knowledge of metabolic and lipid regulation in fibrotic lungs is limited. To comprehensively characterize metabolic...