Critical changes in hypothalamic gene networks in response to pancreatic cancer as found by single-cell RNA sequencing

• Main Authors: Christian Huisman (Author), Mason A. Norgard (Author), Peter R. Levasseur (Author), Stephanie M. Krasnow (Author), Monique G.P. van der Wijst (Author), Brennan Olson (Author), Daniel L. Marks (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Cancer cachexia is a devastating chronic condition characterized by involuntary weight loss, muscle wasting, abnormal fat metabolism, anorexia, and fatigue. However, the molecular mechanisms underlying this syndrome remain poorly understood. In particular, the hypothalamus may play a cent...