Critical changes in hypothalamic gene networks in response to pancreatic cancer as found by single-cell RNA sequencing
Objective: Cancer cachexia is a devastating chronic condition characterized by involuntary weight loss, muscle wasting, abnormal fat metabolism, anorexia, and fatigue. However, the molecular mechanisms underlying this syndrome remain poorly understood. In particular, the hypothalamus may play a cent...
Saved in:
Main Authors: | Christian Huisman (Author), Mason A. Norgard (Author), Peter R. Levasseur (Author), Stephanie M. Krasnow (Author), Monique G.P. van der Wijst (Author), Brennan Olson (Author), Daniel L. Marks (Author) |
---|---|
Format: | Book |
Published: |
Elsevier,
2022-04-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Physiologic and molecular characterization of a novel murine model of metastatic head and neck cancer cachexia
by: Brennan Olson, et al.
Published: (2021) -
Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing
by: Brian Y.H. Lam, et al.
Published: (2017) -
Lipopolysaccharide‐induced hypothalamic inflammation in cancer cachexia‐anorexia is amplified by tumour‐derived prostaglandin E2
by: Xiaolin Li, et al.
Published: (2022) -
RNA-sequencing approach for exploring the protective mechanisms of dexmedetomidine on pancreatic injury in severe acute pancreatitis
by: Jiaqi Yao, et al.
Published: (2023) -
MyD88 signalling is critical in the development of pancreatic cancer cachexia
by: Xinxia Zhu, et al.
Published: (2019)