Inhibition of acetylcholinesterase by two genistein derivatives: kinetic analysis, molecular docking and molecular dynamics simulation

• Main Authors: Jiansong Fang (Author), Ping Wu (Author), Ranyao Yang (Author), Li Gao (Author), Chao Li (Author), Dongmei Wang (Author), Song Wu (Author), Ai-Lin Liu (Author), Guan-Hua Du (Author)
• Format: Book
• Published: Elsevier, 2014-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study two genistein derivatives (G1 and G2) are reported as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and differences in the inhibition of AChE are described. Although they differ in structure by a single methyl group, the inhibitory effect of G1 (IC50=264 ...