Pharmacometabonomic association of cyclophosphamide 4‐hydroxylation in hematopoietic cell transplant recipients

• Main Authors: Jeannine S. McCune (Author), Ryotaro Nakamura (Author), Denis O'Meally (Author), Timothy W. Randolph (Author), Brenda M. Sandmaier (Author), Aleksandra Karolak (Author), David Hockenbery (Author), Sandi L. Navarro (Author)
• Format: Book
• Published: Wiley, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The widely used alkylating agent cyclophosphamide (CY) has substantive interpatient variability in the area under the curve (AUC) of it and its metabolites. Numerous factors may influence the drug‐metabolizing enzymes that metabolize CY to 4‐hydroxycyclophosphamide (4HCY), the principal pre...