Efficient Generation of Pathogenic A-to-G Mutations in Human Tripronuclear Embryos via ABE-Mediated Base Editing

• Main Authors: Guanglei Li (Author), Xinyi Liu (Author), Shisheng Huang (Author), Yanting Zeng (Author), Guang Yang (Author), Zongyang Lu (Author), Yu Zhang (Author), Xu Ma (Author), Lisheng Wang (Author), Xingxu Huang (Author), Jianqiao Liu (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Base editing systems show their power in modeling and correcting the pathogenic mutations of genetic diseases. Previous studies have already demonstrated the editing efficiency of BE3-mediated C-to-T conversion in human embryos. However, the precision and efficiency of a recently developed adenine b...