Computational model for fetal skeletal defects potentially linked to disruption of retinoic acid signaling

• Main Authors: Jocylin D. Pierro (Author), Bhavesh K. Ahir (Author), Nancy C. Baker (Author), Nicole C. Kleinstreuer (Author), Menghang Xia (Author), Thomas B. Knudsen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

All-trans retinoic acid (ATRA) gradients determine skeletal patterning morphogenesis and can be disrupted by diverse genetic or environmental factors during pregnancy, leading to fetal skeleton defects. Adverse Outcome Pathway (AOP) frameworks for ATRA metabolism, signaling, and homeostasis allow fo...