Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo

• Main Authors: Guangyao Lv (Author), Dengjun Sun (Author), Jingwen Zhang (Author), Xiaoxia Xie (Author), Xiaoqiong Wu (Author), Weishuo Fang (Author), Jingwei Tian (Author), Chunhong Yan (Author), Hongbo Wang (Author), Fenghua Fu (Author)
• Format: Book
• Published: Elsevier, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tubulin has been shown to be an effective target for the development of cytotoxic agents against prostate cancer. Previously, we reported that Lx2-32c is an anti-tubulin agent with high binding affinity to tubulin. In this study, we investigated the potential of Lx2-32c to act as an effective cytoto...