Enhancing phase I dose-finding trials design through dynamic borrowing information and handling late-onset toxicity

Introduction: In recent years, there has been a growing trend among regulatory agencies to consider the use of historical controls in clinical trials as a means of improving the efficiency of trial design. In this paper, to enhance the statistical operating characteristic of Phase I dose-finding tri...

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Main Authors: Wenyun Yang (Author), Ruyue He (Author), Yuehan Sun (Author), Fangrong Yan (Author), Fei Wang (Author)
Format: Book
Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
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