Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery

• Main Authors: Paola eImbrici (Author), Antonella eLiantonio (Author), Giulia Maria eCamerino (Author), Michela eDe Bellis (Author), Claudia eCamerino (Author), Antonietta eMele (Author), Arcangela eGiustino (Author), Sabata ePierno (Author), Annamaria eDe Luca (Author), Domenico eTricarico (Author), Jean-Francois eDesaphy (Author), Diana eConte (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the human genome more than 400 genes encode ion channels, which are transmembrane proteins mediating ion fluxes across membranes. Being expressed in all cell types, they are involved in almost all physiological processes, including sense perception, neurotransmission, muscle contraction, secretio...