Paeoniflorin directly binds to TNFR1 to regulate podocyte necroptosis in diabetic kidney disease

• Main Authors: Xian Wang (Author), Xue-qi Liu (Author), Ling Jiang (Author), Yue-bo Huang (Author), Han-xu Zeng (Author), Qi-jin Zhu (Author), Xiang-ming Qi (Author), Yong-gui Wu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Necroptosis was elevated in both tubulointerstitial and glomerular renal tissue in patients with diabetic kidney disease (DKD), and was most pronounced on glomerulus in the stage with macroalbuminuria. This study further explored whether paeoniflorin (PF) could affect podocyte necroptosis to protect...