A GD2-aptamer-mediated, self-assembling nanomedicine for targeted multiple treatments in neuroblastoma theranostics

• Main Authors: Liyu Zhang (Author), Meng Wang (Author), Zeen Zhu (Author), Shengquan Chen (Author), Haibin Wu (Author), Ying Yang (Author), Fengyu Che (Author), Qiao Li (Author), Hui Li (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Because current mainstream anti-glycolipid GD2 therapeutics for neuroblastoma (NB) have limitations, such as severe adverse effects, improved therapeutics are needed. In this study, we developed a GD2 aptamer (DB99) and constructed a GD2-aptamer-mediated multifunctional nanomedicine (ANM) with effec...